Origin of Slides For A Microscope

 An "accidental invention" of a glass craftsman

At the end of the 17th century, when Dutch scientist “Antonie van Leeuwenhoek”used a homemade simple microscope to observe microorganisms, he needed to fix the samples on a transparent medium. At that time, the thin and flat small glass pieces cut by glass craftsmen when making telescope lenses accidentally became ideal carriers. This is the earliest prototype of “Microscope Slide”.

Development: The Industrial revolution promotes standardized production

In the 19th century, with the explosive growth of biological and medical research, glass slides went from manual polishing to “standard Microscope Slide”:

● Material upgrade: from ordinary glass to high-purity borosilicate glass, which is resistant to high temperatures and corrosion.

● Technology innovation: Surface polishing technology reduces optical distortion, and the thickness is unified to “1-1.2mm”(international standard)-standardized slides.

● Functional differentiation: The emergence of frosted edge slides (for easy marking), grooved slides (liquid sample spill prevention), etc.

Classification: "all-round assistant” of modern laboratories

Today's slides can be divided into three categories according to their uses:

1. Conventional slides: 75×25mm standard size, used for pathological sections and cell observation.

2. Specially treated slides:

-Anti-slipping (APES coating): prevent tissue sections from falling off.

-Fluorescent slides: low autofluorescence, suitable for fluorescence microscopes.

3.Disposable sterile slides: pre-sterilized to avoid cross contamination.

Application: How do slides affect experimental results

The quality of the slide directly determines the “accuracy”and “repeatability” of the experiment:

●  Pathological diagnosis: Slides with uneven thickness may cause microscope focus deviation and misjudgment of cell morphology.

●  Immunohistochemistry: Unqualified coating will reduce antibody binding efficiency and produce false negatives.

● Teaching and scientific research: High-transparency slides improve students' observation efficiency.

Case: 

A comparative test in a tertiary hospital found that after using "high-precision slides", the consistency of pathological section diagnosis increased by 23%.

Conclusion: 

Jiangsu Huida Medical Devices - the leader of global slide technology,from Leeuwenhoek's rough glass slide to today's high-tech carrier, microscope slides have witnessed every leap in human science. 

Jiangsu Huida Medical Devices Co., Ltd. has become a reliable partner for global laboratories with the following advantages:

● Borosilicate glass with a purity of 99.9%, optical performance meets ISO 8037 standards.

●  Fully automatic coating process, anti-slip rate is less than 0.1%.

● Customized service, supporting special needs such as fluorescence and conductivity.

The world needs a clearer view, and we provide more reliable slides.